Application

Research Sub CategoryImmunoglobulins & Immunology

This Anti-RIG1 Antibody, clone 42 is validated for use in Western Blotting and Flow Cytometry for the detection of RIG1.

Flow Cytometry Analysis: 0.25 µg of this antibody from a representative lot detected RIG1 in 1X10E6 THP-1 cells.

Research CategoryInflammation & Immunology

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

RIG1 is a cytoplasmically bound enzyme that exhibits phospholipase 1/2 activity and catalyzes the hydrolysis of various important membrane lipids including phosphatidylcholine and phosphatidylethanolamine containing lipids. RIG1 mimics PLA1/2 activities in many tissues and is widely expressed. Recent research has shown that RIG1 also functions as a cytoplasmic pattern receptor that detects viral RNA and acts as a cellular sensor for viral infection, which in turn can activate the proinflammatory response and the production of type-1 interferons against the infection.

Immunogen

Recombinant protein corresponding to human RIG1.

Other Notes

Concentration: Please refer to lot specific datasheet.

Physical form

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Protein G Purified

Format: Purified

Quality

Evaluated by Western Blotting in THP-1 cell lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected RIG1 in 10 µg of THP-1 cell lysate.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~17 kDa observed